Recent publications

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Identification of PRMT5 as a therapeutic target in cholangiocarcinoma. 

Elurbide J, Colyn L, Latasa MU, Uriarte I, Mariani S, Lopez-Pascual A, Valbuena E, Castello-Uribe B, Arnes-Benito R, Adan-Villaescusa E, Martinez-Perez LA, Azkargorta M, Elortza F, Wu H, Krawczyk M, Schneider KM, Sangro B, Aldrighetti L, Ratti F, Casadei Gardini A, Marin JJG, Amat I, Urman JM, Arechederra M, Martinez-Chantar ML, Trautwein C, Huch M, Cubero FJ, Berasain C, G Fernandez-Barrena M, Avila MA. Gut. 2024 Dec 10;74(1):116-127. doi: 10.1136/gutjnl-2024-332998. PMID: 39266051 

New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study. 

Uriarte I, Santamaria E, López-Pascual A, Monte MJ, Argemí J, Latasa MU, Adán-Villaescusa E, Irigaray A, Herranz JM, Arechederra M, Basualdo J, Lucena F, Corrales FJ, Rotellar F, Pardo F, Merlen G, Rainteau D, Sangro B, Tordjmann T, Berasain C, Marín JJG, Fernández-Barrena MG, Herrero I, Avila MA.  Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167166. doi: 10.1016/j.bbadis.2024.167166. 

Refinement of paramagnetic bead-based digestion protocol for automatic sample preparation using an artificial neural network. 

Ciordia S, Milhano Santos F, Dias J.M.L., Lamas J.R., Paradela A, Alvarez-Sola G, Ávila M.A., Corrales F. Talanta. 2024 Jul 1;274:125988. doi: 10.1016/j.talanta.2024.125988. Epub 2024 Mar 23. PMID: 38569368.

Bile as a liquid biopsy matrix: potential applications and limitations. 

Arechederra M,  Rullán M, Oyón D, Urmán JM, Avila MA, Berasain C.

 Explor Dig Dis. 2024 Feb; 3:5–21 doi: https://doi.org/10.37349/edd.2024.00037 

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming. 

Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, Sangro B, Vicent S, Iraburu MJ, Prosper F, Nelson LJ, Banales JM, Martinez-Chantar ML, Marin JJG, Braconi C, Trautwein C, Corrales FJ, Cubero FJ, Berasain C, Fernandez-Barrena MG, Avila MA. 

J Exp Clin Cancer Res. 2022 May 26;41(1):183. doi: 10.1186/s13046-022-02386-2. 

PMID: 35619118 

Bile Processing Protocol for Improved Proteomic Analysis. 

Ciordia S, Alvarez-Sola G, Rullán M, Urman JM, Ávila MA, Corrales FJ.  

Methods Mol Biol. 2022;2420:1-10. doi: 10.1007/978-1-0716-1936-0_1. 

PMID: 34905161. 

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease. 

Chen C, Wu H, Ye H, Tortajada A, Rodríguez-Perales S, Torres-Ruiz R, Vidal A, Peligros MI, Reissing J, Bruns T, Mohamed MR, Zheng K, Lujambio A, Iraburu MJ, Colyn L, Latasa MU, Arechederra M, Fernández-Barrena MG, Berasain C, Vaquero J, Bañares R, Nelson LJ, Trautwein C, Davis RJ, Martinez-Naves E, Nevzorova YA, Villanueva A, Avila MA, Cubero FJ. 

Cancers (Basel). 2021 Dec 24;14(1):78. doi: 10.3390/cancers14010078. 

PMID: 35008241 

Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures.

Arechederra M, Rullán M, Amat I, Oyon D, Zabalza L, Elizalde M, Latasa MU, Mercado MR, Ruiz-Clavijo D, Saldaña C, Fernández-Urién I, Carrascosa J, Jusué V, Guerrero-Setas D, Zazpe C, González-Borja I, Sangro B, Herranz JM, Purroy A, Gil I, Nelson LJ, Vila JJ, Krawczyk M, Zieniewicz K, Patkowski W, Milkiewicz P, Cubero FJ, Alkorta-Aranburu G, G Fernandez-Barrena M, Urman JM, Berasain C, Avila MA.

Gut. 2022 Jun;71(6):1141-1151. doi: 10.1136/gutjnl-2021-325178. 

PMID: 34285068  

Epigenetic Biomarkers for the Diagnosis and Treatment of Liver Disease.

Arechederra M, Recalde M, Gárate-Rascón M, Fernández-Barrena MG, Ávila MA, Berasain C.

Cancers (Basel). 2021 Mar 12;13(6):1265. doi: 10.3390/cancers13061265.  

PMID: 33809263 

Digging deeper into bile proteome. 

 Ciordia S, Alvarez-Sola G, Rullán M, Urman JM, Ávila MA, Corrales FJ. 

J Proteomics. 2021 Jan 6;230:103984. doi: 10.1016/j.jprot.2020.103984. Epub 2020 Sep 12. 

PMID: 32932008. 

Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach.

Urman JM, Herranz JM, Uriarte I, Rullán M, Oyón D, González B, Fernandez-Urién I, Carrascosa J, Bolado F, Zabalza L, Arechederra M, Alvarez-Sola G, Colyn L, Latasa MU, Puchades-Carrasco L, Pineda-Lucena A, Iraburu MJ, Iruarrizaga-Lejarreta M, Alonso C, Sangro B, Purroy A, Gil I, Carmona L, Cubero FJ, Martínez-Chantar ML, Banales JM, Romero MR, Macias RIR, Monte MJ, Marín JJG, Vila JJ, Corrales FJ, Berasain C, Fernández-Barrena MG, Avila MA.

Cancers (Basel). 2020 Jun 21;12(6):1644.  doi: 10.3390/cancers12061644.

PMID: 32575903 

Liquid biopsy for cancer management. A revolutionary but still limited new tool for precision medicine.  

Arechederra M, Avila MA, Berasain C. 

Adv Lab Med. 2020 April 27. doi.org/10.1515/almed-2020-0009